Marie-Carmelle Elie

Marie-Carmelle Elie, MD, FACEP, FCCM, FAAEM, RDMS

Critical Care Research And Clinical Trials Liaison, Division Of Critical Care Medicine; Clinical Associate Professor; Chief Medical Officer, Haven Hospice And Medical Group

Department: MD-EMERGENCY MED-AED
Business Phone: (352) 265-5911

About Marie-Carmelle Elie

Dr. Marie-Carmelle Elie obtained her medical degree from the State University of New York in Brooklyn with distinction in research. Since then, she has continued to distinguish herself as a scholar and clinician investigator. Following her emergency medicine residency at Mount Sinai Medical Center in New York, she completed the prestigious critical care/trauma fellowship at the R. Adam Cowley Shock Trauma Center at the University of Maryland and obtained her certification in hospice-palliative and end-of-life care for emergency medicine. In addition, she is a registered diagnostic medical sonographer.

Dr. Elie’s research focuses on the biomarker detection and the prevention of complications often suffered by critical care patients. She is an expert at designing systems to prevent errors in the critical care setting and has a track record of successful interdepartmental collaborations that result in streamlining acute care in the E.R. As co-chair of the hospital sepsis committee, she is spearheading the hospital-wide sepsis protocols, has instituted the E.R. sepsis alert, and is engaged in plans to establish a community-wide program that will engage neighboring facilities and the prehospital system.

Dr. Elie is involved in numerous high-profile clinical trials. She is a member of the US Critical Illness and Injury Trials Group. She is currently the site principal investigator for the LIPS-A study, an NIH-funded trial that investigates the use of aspirin in preventing acute lung injury, and the PI for Biomarkers of Pediatric Sepsis trial, funded by a competitive University of Florida Faculty Research Development Grant. She has served as co-investigator for a number of critical care trials, including PROWESS-II, the study of drotrecogin alfa in septic shock, and PROMISES (Progenitor Endothelial Cells as a Marker of Endothelial Injury and Repair), which examines angiogenic markers of hypoxia and endothelial injury and the mechanism of repair in sepsis. Dr. Elie has also led research efforts in the area of nosocomial patterns of transmission of methicillin resistant staphylococcus aureus (MRSA), specifically in the health care setting. Her impressive research portfolio has been supported by continuous grant funding since 2008.

In addition to her research accomplishments, Dr. Elie is a masterful clinician educator. Her bedside teaching and formal didactics consistently win acclaim for their clarity, contemporary themes and delivery. What is remarkable about her approach is her enviable ability to distill complicated and often controversial concepts into material that is relevant to the daily practice of the clinician. This incredible agility in thought has been recognized again and again by Faculty of the Year awards.

Board Certifications

  • Critical Care Medicine
    European Board of Intensive Care Medicine
  • Emergency Medicine
    American Board of Emergency Medicine
  • Hospice and Palliative Medicine
    American Board of Emergency Medicine

Clinical Profile

Specialties
  • Emergency Medicine
Subspecialties
  • Critical Care Medicine
  • Hospice and Palliative Medicine
Areas of Interest
  • Acute respiratory distress syndrome
  • Coronavirus disease 2019 (COVID-19)
  • H1N1 influenza (Swine flu)
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Neonatal sepsis
  • Secondary infections
  • Sepsis
  • Septic shock

Publications

2021
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
The New England journal of medicine. 384(9):795-807 [DOI] 10.1056/NEJMoa2031994. [PMID] 33306283.
2020
Boarding of critically Ill patients in the emergency department.
Journal of the American College of Emergency Physicians open. 1(4):423-431 [DOI] 10.1002/emp2.12107. [PMID] 33000066.
2020
Boarding of Critically Ill Patients in the Emergency Department.
Critical care medicine. 48(8):1180-1187 [DOI] 10.1097/CCM.0000000000004385. [PMID] 32697489.
2020
Design and implementation of a clinical decision support tool for primary palliative Care for Emergency Medicine (PRIM-ER).
BMC medical informatics and decision making. 20(1) [DOI] 10.1186/s12911-020-1021-7. [PMID] 31992301.
2020
Effect of Oral Oseltamivir on Virological Outcomes in Low-risk Adults With Influenza: A Randomized Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70(11):2317-2324 [DOI] 10.1093/cid/ciz634. [PMID] 31541242.
2020
Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care.
Neurocritical care. [DOI] 10.1007/s12028-020-01085-0. [PMID] 32959201.
2019
Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial.
The Lancet. Respiratory medicine. 7(11):941-950 [DOI] 10.1016/S2213-2600(19)30199-7. [PMID] 31582360.
2019
Emergency Medicine Palliative Care Access (EMPallA): protocol for a multicentre randomised controlled trial comparing the effectiveness of specialty outpatient versus nurse-led telephonic palliative care of older adults with advanced illness.
BMJ open. 9(1) [DOI] 10.1136/bmjopen-2018-025692. [PMID] 30813112.
2019
External Validation of the qSOFA Score in Emergency Department Patients With Pneumonia.
The Journal of emergency medicine. 57(6):755-764 [DOI] 10.1016/j.jemermed.2019.08.043. [PMID] 31735660.
2019
Primary Palliative Care for Emergency Medicine (PRIM-ER): Protocol for a Pragmatic, Cluster-Randomised, Stepped Wedge Design to Test the Effectiveness of Primary Palliative Care Education, Training and Technical Support for Emergency Medicine.
BMJ open. 9(7) [DOI] 10.1136/bmjopen-2019-030099. [PMID] 31352424.
2018
Corrigendum to “Remote management of low- to intermediate-risk chest pain: a case series” (Am J Emerg Med [2017]).
The American journal of emergency medicine. 36(2) [DOI] 10.1016/j.ajem.2017.10.007. [PMID] 29108799.
2018
Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm – kidney stones (DACA-KS).
BMC medical informatics and decision making. 18(1) [DOI] 10.1186/s12911-018-0652-4. [PMID] 30119627.
2017
Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study.
The Lancet. Respiratory medicine. 5(6):500-511 [DOI] 10.1016/S2213-2600(17)30174-1. [PMID] 28522352.
2017
Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial.
The Lancet. Infectious diseases. 17(12):1255-1265 [DOI] 10.1016/S1473-3099(17)30476-0. [PMID] 28958678.
2016
Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial.
JAMA. 315(22):2406-14 [DOI] 10.1001/jama.2016.6330. [PMID] 27179988.
2016
The incidence and significance of acute kidney injury following emergent contrast administration in patients with STEMI and stroke.
Internal and emergency medicine. 11(6):853-7 [DOI] 10.1007/s11739-016-1407-9. [PMID] 26910240.
2016
Trauma Simulation Training Increases Confidence Levels in Prehospital Personnel Performing Life-Saving Interventions in Trauma Patients.
Emergency medicine international. 2016 [DOI] 10.1155/2016/5437490. [PMID] 27563467.
2015
An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA.
Clinical toxicology (Philadelphia, Pa.). 53(10):950-6 [DOI] 10.3109/15563650.2015.1100306. [PMID] 26555732.
2015
Evaluation of healthcare use trends of high-risk female intimate partner violence victims.
The western journal of emergency medicine. 16(1):107-13 [DOI] 10.5811/westjem.2014.12.22866. [PMID] 25671018.
2015
Palliative Care Symptom Management.
Critical care nursing clinics of North America. 27(3):315-39 [DOI] 10.1016/j.cnc.2015.05.010. [PMID] 26333754.
2015
SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk.
Journal of intensive care medicine. 30(4):209-16 [DOI] 10.1177/0885066613516411. [PMID] 24362445.
2014
Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 10(6):657-62 [DOI] 10.5664/jcsm.3794. [PMID] 24932146.
2014
Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study.
Mayo Clinic proceedings. 89(2):154-62 [DOI] 10.1016/j.mayocp.2013.10.028. [PMID] 24485129.
2013
Contemporary ventilator management in patients with and at risk of ALI/ARDS.
Respiratory care. 58(4):578-88 [DOI] 10.4187/respcare.01755. [PMID] 22906363.
2013
Emergency department crowding and time to antibiotic administration in febrile infants.
The western journal of emergency medicine. 14(5):518-24 [DOI] 10.5811/westjem.2013.1.14693. [PMID] 24106552.
2013
Impact of helmet use in traumatic brain injuries associated with recreational vehicles.
Advances in preventive medicine. 2013 [DOI] 10.1155/2013/450195. [PMID] 24205441.
2013
Mesenteric infarction due to iatrogenic polycythemia.
World journal of emergency medicine. 4(3):232-4 [DOI] 10.5847/wjem.j.1920-8642.2013.03.014. [PMID] 25215125.
2013
Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk.
Journal of critical care. 28(6):985-91 [DOI] 10.1016/j.jcrc.2013.08.011. [PMID] 24075297.
2013
TBI surveillance using the common data elements for traumatic brain injury: a population study.
International journal of emergency medicine. 6(1) [DOI] 10.1186/1865-1380-6-5. [PMID] 23445771.
2013
The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes.
Critical care medicine. 41(7):1679-85 [DOI] 10.1097/CCM.0b013e31828a1fc7. [PMID] 23660730.
2012
Lung injury prediction score for the emergency department: first step towards prevention in patients at risk.
International journal of emergency medicine. 5(1) [DOI] 10.1186/1865-1380-5-33. [PMID] 22943391.
2012
Lung Injury Prevention with Aspirin (LIPS-A): a protocol for a multicentre randomised clinical trial in medical patients at high risk of acute lung injury.
BMJ open. 2(5) [DOI] 10.1136/bmjopen-2012-001606. [PMID] 22952165.
2012
Prehospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk.
Journal of critical care. 27(5):447-53 [DOI] 10.1016/j.jcrc.2011.10.009. [PMID] 22226422.
2012
Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk – a multicenter cohort study.
International journal of emergency medicine. 5(1) [DOI] 10.1186/1865-1380-5-22. [PMID] 22632126.
2011
Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients.
Critical care medicine. 39(11):2393-400 [DOI] 10.1097/CCM.0b013e318225757f. [PMID] 21725238.
2011
Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study.
American journal of respiratory and critical care medicine. 183(4):462-70 [DOI] 10.1164/rccm.201004-0549OC. [PMID] 20802164.
2010
Prevalence and characteristics of Staphylococcus aureus colonization among healthcare professionals in an urban teaching hospital.
Infection control and hospital epidemiology. 31(6):574-80 [DOI] 10.1086/652525. [PMID] 20426580.
2006
Blunt cardiac injury.
The Mount Sinai journal of medicine, New York. 73(2):542-52 [PMID] 16568196.
View on: PubMed
1997
Maternal serum vitamin A levels are not associated with mother-to-child transmission of HIV-1 in the United States.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 14(4):321-6 [PMID] 9111473.
View on: PubMed

Grants

Oct 2020 ACTIVE
COVID-19: A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic Strategies in Hospitals Adults with COVID-19
Role: Principal Investigator
Funding: NEW YORK UNIV via NATL INST OF HLTH NHLBI
Aug 2020 – Feb 2021
Passive Immunity Trial for Our Neighbors (PassItOn): A randomized, placebocontrolled multi-site trial of anti-SARS-CoV-2 convalescent plasma to treat hospitalized adults with COVID-19
Role: Principal Investigator
Funding: VANDERBILT UNIV MEDICAL CENTER via NATL INST OF HLTH NCATS
Apr 2020 ACTIVE
Biology and Longitudinal Epidemiology of COVID-19 Observational Study, BLUE CORAL
Role: Principal Investigator
Funding: BAYSTATE MEDICAL CENTER via NATL INST OF HLTH
Apr 2020 – Jul 2020
Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease (ORCHID)
Role: Principal Investigator
Funding: BAYSTATE MEDICAL CENTER via NATL INST OF HLTH NHLBI
Mar 2020 ACTIVE
A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Role: Co-Investigator
Funding: LEIDOS via NATL INST OF HLTH NIAID
Sep 2019 ACTIVE
ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA)
Role: Principal Investigator
Funding: STANFORD UNIV via NATL INST OF HLTH NHLBI
May 2019 ACTIVE
VITAS – Education – Primary Palliative Care for Emergency Medicine
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Sep 2018 ACTIVE
Acute Lung Injury Group New England Program to Support PETAL Network Research (PETAL Core)
Role: Principal Investigator
Funding: BAYSTATE MEDICAL CENTER via NATL INST OF HLTH NHLBI
May 2018 ACTIVE
Primary Palliative Care for Emergency Medicine
Role: Principal Investigator
Funding: NEW YORK UNIVERSITY SCHOOL OF MEDICINE via NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
May 2018 ACTIVE
CLOVERS: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Role: Principal Investigator
Funding: BAYSTATE MEDICAL CENTER via NATL INST OF HLTH NHLBI
Dec 2017 ACTIVE
Emergency Medicine-Initiated Palliative Care In Older Adults (EMPallA)
Role: Principal Investigator
Funding: NEW YORK UNIVERSITY SCHOOL OF MEDICINE via PATIENT-CENTERED OUTCOMES RES INST
Aug 2016 – Sep 2018
A Randomized Double-Blind Study Comparing Oseltamivir versus Placebo for the Treatment of Influenza in Low Risk Adults
Role: Principal Investigator
Funding: SOCIAL AND SCIENTIFIC SYSTEMS via NATL INST OF HLTH NIAID
Nov 2015 – Sep 2016
A RANDOMIZED DOUBLE BLIND PHASE 2 STUDY COMPARING THE EFFICACY, SAFETY, AND TOLERABILITY OF COMBINATION ANTIVIRALS (Amantadine, Ribavirin,Oseltamivir) versus Oseltamivir for the Treatment of Influenza
Role: Principal Investigator
Funding: SOCIAL AND SCIENTIFIC SYSTEMS via NATL INST OF HLTH NIAID
Nov 2015 – Jun 2016
A Randomized Open-Label, Phase 2, Multicenter Safety and Exploratory Efficacy Study of Investigational anti-Influenza Immune Plasma for the Treatment of Influenza
Role: Principal Investigator
Funding: SOCIAL AND SCIENTIFIC SYSTEMS via NATL INST OF HLTH NIAID
Oct 2015 – Jun 2019
a randomized double blind phase 3 study comparing the efficacy and safety of high titer versus low titer anti influenza immune plasma for the treatment of severe influenza
Role: Principal Investigator
Funding: SOCIAL AND SCIENTIFIC SYSTEMS via NATL INST OF HLTH NIAID
Apr 2015 – Oct 2015
Influenza Studies IRC003 and IRC004 Domestic Operations
Role: Principal Investigator
Funding: SOCIAL AND SCIENTIFIC SYSTEMS via LEIDOS
Jan 2014 – Jan 2017
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study Evaluating the Safety and Efficacy of Icatibant as a Treatment for Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema in Adults
Role: Principal Investigator
Funding: SHIRE PHARMACEUTICAL DEV

Education

Fellowship – Trauma and Surgical Critical Care
2004 · University of Maryland
Residency – Emergency Medicine
2003 · Mount Sinai Medical Center
Medical School
1999 · State University of New York Downstate
Bachelor of Arts
1995 · Columbia University

Teaching Profile

Courses Taught
2018
MDT7710 Elec Topic Emerg Med
2018
MDT7090 Elective Topics
2018
MDC7710 Sr Emerg Med Clerkshp
2018
MDC7400 Pediatric Clerkship
2014
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 265-5911
Research Administrative Support Assistant, II:
Debra J Beck
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