The High Sensitivity Cardiac Troponin T to Optimize Chest Pain Risk Stratification (STOP CP) study is a prospective observational cohort study of ED patients with acute chest pain with the primary objective being to establish the safety and efficacy of Roche hs-cTnT in patients with acute chest pain in the emergency department. There will be approximately 1,500 participants enrolled in this study across six sites in the US. This important study aims to safely achieve higher early discharge rates by combining the Roche hs-cTnT values with clinical variables. The study is funded by Roche and UF will serve as the coordinating center for the trial.