Faculty Research Projects

Our faculty are actively involved in a variety of clinical research areas:

  • High-Sensitivity Cardiac Troponin T to Optimize Chest Pain Risk Stratification (STOP CP)
    Principal Investigator:
    Brandon Allen, MD
  • A Randomized Double-Blind, Phase 3 Study Comparing the Efficacy and Safety of High-Titer versus Low-Titer Anti-Influenza Immune Plasma for the Treatment of Severe Influenza A (IRC-005)
    Principal Investigator:
    Marie-Carmelle Elie, MD
  • Long Term Cognitive Impact of Pediatric Acute Renal Injury
    Principal Investigator:
    Marie-Carmelle Elie, MD
  • Serum biomarkers in sepsis associated encephalopathy
    Principal Investigator:
    Marie-Carmelle Elie, MD
  • Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM)
    Principal Investigator:
    Michael Marchick, MD
  • Music in Urgent and Emergent Settings (MUES) Trial: Phase Three
    Principal Investigator:
    J. Adrian Tyndall, MD
  • Molecular epidemiology and phylodynamic and phylogeographic analysis of Community-associated Methicillin-resistant Staphylococcus aureus transmission: An Emergency Department Population Sampling Strategy
    Principal Investigator:
    J. Adrian Tyndall, MD
  • NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
    Principal Investigator:
    Kevin Wang, PhD
  • Predicting neurological outcome following out of hospital cardiac arrest (OHCA) by quantitative measurement of serial serum biomarkers of brain injury
    Principal Investigator:
    J. Adrian Tyndall, MD
  • Evaluation of Tau and Phospho-Tau as TBI Biomarkers on the iCT-HISCL Platform
    Principal Investigator:
    Kevin Wang, PhD
  • TBI Endpoints Development (TED)
    Principal Investigator:
    Kevin Wang, PhD
  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury
    Principal Investigator:
    Kevin Wang, PhD
  • TGF-BETA Signaling-Novel Therapeutic Target for Mild TBI
    Principal Investigator:
    Kevin Wang, PhD

Current Emergency Medicine Clinical Trials

EMPallA: Emergency Medicine Palliative Care Access

Principal Investigator:
Marie-Carmelle Elie, MD

Study Coordinator:
Rebecca Murray

Study Description:
This is a two-arm, multi-site randomized controlled trial of 1,350 older adults (50+ years) with either advanced cancer (defined as metastatic solid tumor) or end-stage organ failure (New York Heart Association (NYHA) Class III and IV Heart Failure, End Stage Renal Disease defined as GFR < 15 ml/min/m2; or Global Initiative for Chronic Obstructive Lung Disease (GOLD) Stage III and higher or oxygen-dependent chronic obstructive pulmonary disease (COPD) defined as FEV1 < 50% or the mMRC dyspnea scale) who present to the Emergency Department (ED), along with 675 of their informal caregivers, to compare nurse-led telephonic case management to facilitated, outpatient specialty palliative care. Investigators will compare effectiveness of two distinct palliative care models that vary by provider type (nurse versus physician-led) and mode of delivery (telephonic versus in-person): a) nurse-led telephonic case management; and b) facilitated, outpatient specialty palliative care.

Study Sponsor:
PCORI

CLOVERS: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis

 Principal Investigator:
Marie-Carmelle Elie, MD

Study Coordinator:
Amy Holland

Study Description:
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.

Study Sponsor:
NIH

XEPOHCAS

Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management [TTM]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM).

Principal Investigator:
Torben K. Becker MD, PhD, RDMS, FAWM

Study Coordinator:
Cindy Montero

Study Description:
XePOHCAS is a prospective, randomized, multicenter, interventional trial in adult subjects (≥18 years) with out of hospital cardiac arrest (OHCA) in which the standard-of-care for post–cardiac arrest intensive care including targeted temperature management (TTM) is compared to the same treatment with the addition of 50% xenon by inhalation.

Study Sponsor:
NeuoproteXeon, Inc.

CHF-01-18: Feasibility Evaluation of the Access Brain Natriuretic Peptide Assay(S) as an Aid in the Diagnosis and Assessment of Severity of Heart Failure – Subject Enrollment and Specimen collection 

Principal Investigator:
Brandon R. Allen, MD

Study Coordinator:
Emmett Martin

Study Description:
This study is screening and enrolling patients (≥21 years) with potential heart failure in the differential diagnosis or who have a BNP ordered during their ED stay. Study involves one blood draw and sample processing.

Study Sponsor:
Beckman Coulter, Inc.