Kevin K Wang

Kevin K Wang, Ph.D.

Professor & Program Director NNBR

Department: Department of Emergency Medicine
Business Phone: (352) 294-4933
Business Email: kwang@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9343-6473

Publications

2021
Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis.
Journal of neurotrauma. 38(8):1086-1106 [DOI] 10.1089/neu.2017.5182. [PMID] 29020853.
2021
Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.
Neurotrauma reports. 2(1):193-199 [DOI] 10.1089/neur.2020.0037. [PMID] 33937911.
2021
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950). [DOI] 10.4049/jimmunol.2001309. [PMID] 34145056.
2021
Elevation of Pro-inflammatory and Anti-inflammatory Cytokines in Rat Serum after Acute Methamphetamine Treatment and Traumatic Brain Injury.
Journal of molecular neuroscience : MN. [DOI] 10.1007/s12031-021-01886-8. [PMID] 34542809.
2021
Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury.
Journal of neurotrauma. 38(13):1870-1878 [DOI] 10.1089/neu.2020.7317. [PMID] 33191835.
2021
Glibenclamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 38(5):628-645 [DOI] 10.1089/neu.2020.7421. [PMID] 33203303.
2021
High-Sensitivity C-Reactive Protein is a Prognostic Biomarker of Six-Month Disability after Traumatic Brain Injury: Results from the TRACK-TBI Study.
Journal of neurotrauma. 38(7):918-927 [DOI] 10.1089/neu.2020.7177. [PMID] 33161875.
2021
Identification of clinically relevant biomarkers of epileptogenesis – a strategic roadmap.
Nature reviews. Neurology. 17(4):231-242 [DOI] 10.1038/s41582-021-00461-4. [PMID] 33594276.
2021
In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery.
Acta neuropathologica communications. 9(1) [DOI] 10.1186/s40478-021-01165-y. [PMID] 33902685.
2021
Kollidon VA64 Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 38(17):2454-2472 [DOI] 10.1089/neu.2021.0089. [PMID] 33843262.
2021
Potentiating Hemorrhage in a Periadolescent Rat Model of Closed-Head Traumatic Brain Injury Worsens Hyperexcitability but Not Behavioral Deficits.
International journal of molecular sciences. 22(12) [DOI] 10.3390/ijms22126456. [PMID] 34208666.
2021
Single Mild Traumatic Brain Injury Deteriorates Progressive Interhemispheric Functional and Structural Connectivity.
Journal of neurotrauma. 38(4):464-473 [DOI] 10.1089/neu.2018.6196. [PMID] 30931824.
2021
Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury.
Acute medicine & surgery. 8(1) [DOI] 10.1002/ams2.622. [PMID] 33510896.
2021
Ultra-early serum concentrations of neuronal and astroglial biomarkers predict poor neurological outcome after out-of-hospital cardiac arrest-a pilot neuroprognostic study.
Resuscitation plus. 7 [DOI] 10.1016/j.resplu.2021.100133. [PMID] 34223394.
2020
Acute Effects of Sport-Related Concussion on Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay.
Journal of neurotrauma. 37(13):1537-1545 [DOI] 10.1089/neu.2019.6831. [PMID] 32024456.
2020
Altered monoaminergic levels, spasticity, and balance disability following repetitive blast-induced traumatic brain injury in rats.
Brain research. 1747 [DOI] 10.1016/j.brainres.2020.147060. [PMID] 32828734.
2020
Anti-Pituitary and Anti-Hypothalamus Autoantibody Associations with Inflammation and Persistent Hypogonadotropic Hypogonadism in Men with Traumatic Brain Injury.
Journal of neurotrauma. 37(14):1609-1626 [DOI] 10.1089/neu.2019.6780. [PMID] 32111134.
2020
Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study.
EBioMedicine. 56 [DOI] 10.1016/j.ebiom.2020.102785. [PMID] 32464528.
2020
Case Study of a Breacher: Investigation of Neurotrauma Biomarker Levels, Self-reported Symptoms, and Functional MRI Analysis Before and After Exposure to Measured Low-Level Blast.
Military medicine. 185(3-4):e513-e517 [DOI] 10.1093/milmed/usz185. [PMID] 31429467.
2020
Circulating GFAP and Iba-1 levels are associated with pathophysiological sequelae in the thalamus in a pig model of mild TBI.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-70266-w. [PMID] 32770054.
2020
Drug Repurposing in Neurological Disorders: Implications for Neurotherapy in Traumatic Brain Injury.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. [DOI] 10.1177/1073858420961078. [PMID] 33089741.
2020
Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy.
Journal of the American Chemical Society. 142(8):3862-3872 [DOI] 10.1021/jacs.9b11490. [PMID] 31991082.
2020
Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.
Journal of neurotrauma. 37(13):1574-1586 [DOI] 10.1089/neu.2019.6537. [PMID] 31973644.
2020
Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.
Journal of neurotrauma. 37(23):2460-2467 [DOI] 10.1089/neu.2020.7140. [PMID] 32854584.
2020
Protein Degradome of Spinal Cord Injury: Biomarkers and Potential Therapeutic Targets.
Molecular neurobiology. 57(6):2702-2726 [DOI] 10.1007/s12035-020-01916-3. [PMID] 32328876.
2020
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
PloS one. 15(7) [DOI] 10.1371/journal.pone.0224952. [PMID] 32692785.
2020
The Role of Blood Biomarkers for Magnetic Resonance Imaging Diagnosis of Traumatic Brain Injury.
Medicina (Kaunas, Lithuania). 56(2) [DOI] 10.3390/medicina56020087. [PMID] 32098419.
2020
Traumatic brain injury and methamphetamine: A double-hit neurological insult.
Journal of the neurological sciences. 411 [DOI] 10.1016/j.jns.2020.116711. [PMID] 32035311.
2019
Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study.
The Lancet. Neurology. 18(10):953-961 [DOI] 10.1016/S1474-4422(19)30282-0. [PMID] 31451409.
2019
Copenhagen Head Injury Ciclosporin Study: A Phase IIa Safety, Pharmacokinetics, and Biomarker Study of Ciclosporin in Severe Traumatic Brain Injury Patients.
Journal of neurotrauma. 36(23):3253-3263 [DOI] 10.1089/neu.2018.6369. [PMID] 31210099.
2019
Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats.
Epilepsy & behavior : E&B. 92:332-340 [DOI] 10.1016/j.yebeh.2019.01.023. [PMID] 30769278.
2019
Neurochemical biomarkers in spinal cord injury.
Spinal cord. 57(10):819-831 [DOI] 10.1038/s41393-019-0319-8. [PMID] 31273298.
2019
Neurological Exam in Rats Following Stroke and Traumatic Brain Injury.
Methods in molecular biology (Clifton, N.J.). 2011:371-381 [DOI] 10.1007/978-1-4939-9554-7_21. [PMID] 31273710.
2019
Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation.
Frontiers in neurology. 10 [DOI] 10.3389/fneur.2019.00124. [PMID] 30915013.
2019
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges.
International journal of molecular sciences. 20(20) [DOI] 10.3390/ijms20205213. [PMID] 31640160.
2019
Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.
Journal of neurotrauma. 36(2):348-359 [DOI] 10.1089/neu.2017.5586. [PMID] 29987972.
2018
Age-Related Differences in Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein and Tau for Identifying Acute Intracranial Trauma on Computed Tomography: A TRACK-TBI Study.
Journal of neurotrauma. 35(20):2341-2350 [DOI] 10.1089/neu.2018.5694. [PMID] 29717620.
2018
An update on diagnostic and prognostic biomarkers for traumatic brain injury.
Expert review of molecular diagnostics. 18(2):165-180 [DOI] 10.1080/14737159.2018.1428089. [PMID] 29338452.
2018
Correction to: Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.
Molecular neurobiology. 55(7) [DOI] 10.1007/s12035-018-0909-z. [PMID] 29344927.
2018
Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Molecular neurobiology. 55(1):898-900 [DOI] 10.1007/s12035-017-0764-3. [PMID] 28975597.
2018
Identification and Characterization of DNA Aptamers Specific for Phosphorylation Epitopes of Tau Protein.
Journal of the American Chemical Society. 140(43):14314-14323 [DOI] 10.1021/jacs.8b08645. [PMID] 30277395.
2018
Longitudinal Investigation of Neurotrauma Serum Biomarkers, Behavioral Characterization, and Brain Imaging in Soldiers Following Repeated Low-Level Blast Exposure (New Zealand Breacher Study).
Military medicine. 183(suppl_1):28-33 [DOI] 10.1093/milmed/usx186. [PMID] 29635591.
2018
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond.
Frontiers in neurology. 9 [DOI] 10.3389/fneur.2018.00640. [PMID] 30131759.
2018
Operation Brain Trauma Therapy: 2016 Update.
Military medicine. 183(suppl_1):303-312 [DOI] 10.1093/milmed/usx184. [PMID] 29635589.
2018
Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
Behavioural brain research. 340:14-22 [DOI] 10.1016/j.bbr.2017.04.025. [PMID] 28419850.
2018
Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant Traumatic Brain Injury Biomarkers.
Journal of neurotrauma. [DOI] 10.1089/neu.2017.5623. [PMID] 29690824.
2018
Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.
Molecular neurobiology. 55(7):6112-6128 [DOI] 10.1007/s12035-017-0821-y. [PMID] 29188495.
2018
Protein Characterization of Extracellular Microvesicles/Exosomes Released from Cytotoxin-Challenged Rat Cerebrocortical Mixed Culture and Mouse N2a Cells.
Molecular neurobiology. 55(3):2112-2124 [DOI] 10.1007/s12035-017-0474-x. [PMID] 28283886.
2018
PrPC expression and calpain activity independently mediate the effects of closed head injury in mice.
Behavioural brain research. 340:29-40 [DOI] 10.1016/j.bbr.2016.04.041. [PMID] 27188531.
2018
Quantitative pupillometry and neuron-specific enolase independently predict return of spontaneous circulation following cardiogenic out-of-hospital cardiac arrest: a prospective pilot study.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-34367-x. [PMID] 30374189.
2018
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Molecular neurobiology. 55(3):2174-2184 [DOI] 10.1007/s12035-017-0424-7. [PMID] 28290147.
2018
Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma.
Journal of neurotrauma. 35(1):32-40 [DOI] 10.1089/neu.2017.4994. [PMID] 28895474.
2018
The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis
Brain Injury. 32(1):1-17 [DOI] 10.1080/02699052.2017.1382717. [PMID] 29087740.
2017
Apolipoprotein E epsilon 4 (APOE-ε4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.
Brain and behavior. 7(9) [DOI] 10.1002/brb3.791. [PMID] 28948085.
2017
Calpain Zymography: General Methodology and Protocol.
Methods in molecular biology (Clifton, N.J.). 1626:279-285 [DOI] 10.1007/978-1-4939-7111-4_26. [PMID] 28608220.
2017
Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.
JAMA neurology. 74(9):1063-1072 [DOI] 10.1001/jamaneurol.2017.0655. [PMID] 28738126.
2017
COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 35:109-116 [DOI] 10.1016/j.jocn.2016.09.017. [PMID] 27769642.
2017
DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury.
Neurogenetics. 18(1):29-38 [DOI] 10.1007/s10048-016-0500-6. [PMID] 27826691.
2017
Hypothesis: Exosomal microRNAs as potential biomarkers for schizophrenia.
Medical hypotheses. 103:21-25 [DOI] 10.1016/j.mehy.2017.04.003. [PMID] 28571801.
2017
Imaging Neural Plasticity following Brain Injury.
Neural plasticity. 2017 [DOI] 10.1155/2017/2083294. [PMID] 28348894.
2017
In Vitro Neurotoxicity Resulting from Exposure of Cultured Neural Cells to Several Types of Nanoparticles.
Journal of cell death. 10 [DOI] 10.1177/1179670717694523. [PMID] 28469474.
2017
Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-01772-7. [PMID] 28694468.
2017
MicroRNAs as potential prognosticators of neurological outcome in out-of-hospital cardiac arrest patients.
Biomarkers in medicine. 11(12):1113-1123 [DOI] 10.2217/bmm-2017-0215. [PMID] 29219009.
2017
Raising the Bar for Traumatic Brain Injury Biomarker Research: Methods Make a Difference.
Journal of neurotrauma. 34(13):2187-2189 [DOI] 10.1089/neu.2017.5030. [PMID] 28322619.
2017
The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries.
Current neurology and neuroscience reports. 17(3) [DOI] 10.1007/s11910-017-0736-z. [PMID] 28283963.
2017
The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration To Accelerate Diagnosis and Treatment of Traumatic Brain Injury.
Journal of neurotrauma. 34(19):2721-2730 [DOI] 10.1089/neu.2016.4729. [PMID] 28363253.
2017
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research.
The Lancet. Neurology. 16(12):987-1048 [DOI] 10.1016/S1474-4422(17)30371-X. [PMID] 29122524.
2017
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Expert opinion on therapeutic targets. 21(6):627-638 [DOI] 10.1080/14728222.2017.1321635. [PMID] 28434268.
2016
A Panel of Serum MiRNA Biomarkers for the Diagnosis of Severe to Mild Traumatic Brain Injury in Humans.
Scientific reports. 6 [DOI] 10.1038/srep28148. [PMID] 27338832.
2016
A Repetitive Concussive Head Injury Model in Mice.
Journal of visualized experiments : JoVE. (116) [DOI] 10.3791/54530. [PMID] 27768069.
2016
Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):513-22 [DOI] 10.1089/neu.2015.4113. [PMID] 26439468.
2016
COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.
Neurogenetics. 17(1):31-41 [DOI] 10.1007/s10048-015-0467-8. [PMID] 26576546.
2016
Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):553-66 [DOI] 10.1089/neu.2015.4122. [PMID] 26671075.
2016
Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury.
Molecular & cellular proteomics : MCP. 15(7):2379-95 [DOI] 10.1074/mcp.M116.058115. [PMID] 27150525.
2016
Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):538-52 [DOI] 10.1089/neu.2015.4116. [PMID] 26670694.
2016
Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures.
Molecular neurobiology. 53(7):4821-32 [DOI] 10.1007/s12035-015-9407-8. [PMID] 26337296.
2016
Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):595-605 [DOI] 10.1089/neu.2015.4132. [PMID] 26671651.
2016
Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):581-94 [DOI] 10.1089/neu.2015.4131. [PMID] 26671550.
2016
Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.
Frontiers in neurology. 7 [PMID] 27920753.
View on: PubMed
2016
Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):523-37 [DOI] 10.1089/neu.2015.4115. [PMID] 26670792.
2016
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(9):1378-1389 [DOI] 10.1016/j.euroneuro.2016.07.007. [PMID] 27461514.
2016
Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study.
Journal of neurotrauma. 33(13):1270-7 [DOI] 10.1089/neu.2015.3881. [PMID] 26560343.
2016
Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):567-80 [DOI] 10.1089/neu.2015.4130. [PMID] 26541177.
2016
Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.
Journal of neurotrauma. 33(6):606-14 [DOI] 10.1089/neu.2015.4133. [PMID] 26671284.
2016
The Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of Rats.
PloS one. 11(4) [DOI] 10.1371/journal.pone.0151034. [PMID] 27082425.
2016
Topical Therapy with Mesenchymal Stem Cells Following an Acute Experimental Head Injury Has Benefits in Motor-Behavioral Tests for Rodents.
Acta neurochirurgica. Supplement. 122:21-4 [DOI] 10.1007/978-3-319-22533-3_4. [PMID] 27165870.
2015
A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids.
Journal of neurotrauma. 32(5):342-52 [DOI] 10.1089/neu.2014.3548. [PMID] 25177776.
2015
Acute diagnostic biomarkers for spinal cord injury: review of the literature and preliminary research report.
World neurosurgery. 83(5):867-78 [DOI] 10.1016/j.wneu.2013.03.012. [PMID] 23524031.
2015
Biomarker identification in psychiatric disorders: from neuroscience to clinical practice.
Journal of psychiatric practice. 21(1):37-48 [DOI] 10.1097/01.pra.0000460620.87557.02. [PMID] 25603450.
2015
Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury.
Neurocritical care. 22(1):52-64 [DOI] 10.1007/s12028-014-0028-2. [PMID] 25052159.
2015
Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Molecular neurobiology. 52(1):696-709 [DOI] 10.1007/s12035-014-8898-z. [PMID] 25270371.
2015
Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker.
Trends in neurosciences. 38(6):364-74 [DOI] 10.1016/j.tins.2015.04.003. [PMID] 25975510.
2015
Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury.
Journal of neurotrauma. 32(17):1307-11 [DOI] 10.1089/neu.2014.3696. [PMID] 25752227.
2015
Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model.
Scientific reports. 5 [DOI] 10.1038/srep11178. [PMID] 26058556.
2015
The functional and structural changes in the basilar artery due to overpressure blast injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 35(12):1950-6 [DOI] 10.1038/jcbfm.2015.151. [PMID] 26104291.
2014
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein.
Journal of neurotrauma. 31(1):19-25 [DOI] 10.1089/neu.2013.3040. [PMID] 23865516.
2014
Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury.
Brain research. 1574:105-12 [DOI] 10.1016/j.brainres.2014.05.046. [PMID] 24929209.
2014
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(9):1444-52 [DOI] 10.1038/jcbfm.2014.105. [PMID] 24917042.
2014
GFAP out-performs S100β in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions.
Journal of neurotrauma. 31(22):1815-22 [DOI] 10.1089/neu.2013.3245. [PMID] 24903744.
2014
Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0092698. [PMID] 24667434.
2014
Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat.
Toxicological sciences : an official journal of the Society of Toxicology. 141(2):398-408 [DOI] 10.1093/toxsci/kfu136. [PMID] 25015659.
2014
Overpressure Blast Injury Induced Structural and Functional Changes in the Brain and Basilar Artery
Journal of Neurotrauma. 31(12)
2014
Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects.
Neural regeneration research. 9(9):901-6 [DOI] 10.4103/1673-5374.133129. [PMID] 25206908.
2014
Wave Heave Energy Conversion Using Modular Multistability
Applied Energy. 130(1, SI):148-156 [DOI] 10.1016/j.apenergy.2014.05.038.
2013
Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury.
Frontiers in neurology. 4 [DOI] 10.3389/fneur.2013.00186. [PMID] 24312074.
2013
Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury.
Journal of neurotrauma. 30(13):1161-9 [DOI] 10.1089/neu.2012.2762. [PMID] 23409698.
2013
Hypothesizing that designer drugs containing cathinones (“bath salts”) have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption.
Medical hypotheses. 81(3):450-5 [DOI] 10.1016/j.mehy.2013.06.007. [PMID] 23845561.
2013
Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.
Neuroscience letters. 544:62-7 [DOI] 10.1016/j.neulet.2013.03.042. [PMID] 23570732.
2013
Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.
Acta neurochirurgica. Supplement. 118:77-81 [DOI] 10.1007/978-3-7091-1434-6_13. [PMID] 23564108.
2013
Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 14(3):310-7 [DOI] 10.1097/PCC.0b013e3182720642. [PMID] 23392373.
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Differential Effect of Nicotinamide On Serum Damage Marker Profiles Following Controlled Cortical Impact, Parasagittal Fluid Percussion, and Penetrating Ballistic-Like Brain Injury: Results From Operation Brain Trauma Therapy
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Journal of Neurotrauma. 21(10):1443-56 [DOI] 10.1089/neu.2004.21.1443. [PMID] 15672634.
2004
Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 24(1):98-106 [PMID] 14688621.
View on: PubMed
2004
Biomarkers of proteolytic damage following traumatic brain injury.
Brain pathology (Zurich, Switzerland). 14(2):202-9 [PMID] 15193033.
View on: PubMed
2004
Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats.
Journal of neurochemistry. 88(3):689-97 [PMID] 14720218.
View on: PubMed
2004
Cell-specific upregulation of survivin after experimental traumatic brain injury in rats.
Journal of neurotrauma. 21(9):1183-95 [PMID] 15453988.
View on: PubMed
2004
Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats.
Journal of Neurotrauma. 21(7):829-41 [DOI] 10.1089/0897715041526177. [PMID] 15307896.
2004
Increased expression and processing of caspase-12 after traumatic brain injury in rats.
Journal of neurochemistry. 88(1):78-90 [PMID] 14675152.
View on: PubMed
2004
Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in rats.
Journal of neurochemistry. 89(5):1301-7 [PMID] 15147523.
View on: PubMed
2004
Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors.
Stem cells and development. 13(6):685-93 [PMID] 15684836.
View on: PubMed
2004
Molecular cloning and characterization of rat and human calpain-5.
Biochemical and biophysical research communications. 324(1):46-51 [PMID] 15464980.
View on: PubMed
2004
Proteomics studies of traumatic brain injury.
International review of neurobiology. 61:215-40 [PMID] 15482817.
View on: PubMed
2003
A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor.
Journal of molecular biology. 328(1):131-46 [PMID] 12684003.
View on: PubMed
2003
Cytochrome c translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y neuroblastoma cells.
Neurochemistry international. 42(6):517-23 [PMID] 12547651.
View on: PubMed
2003
Repeated amphetamine treatment induces neurite outgrowth and enhanced amphetamine-stimulated dopamine release in rat pheochromocytoma cells (PC12 cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.
Journal of neurochemistry. 87(6):1546-57 [PMID] 14713310.
View on: PubMed
2003
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.
Journal of medicinal chemistry. 46(5):868-71 [PMID] 12593666.
View on: PubMed
2002
Assaying proteases in cellular environments.
Current protocols in protein science. Chapter 21 [DOI] 10.1002/0471140864.ps2112s27. [PMID] 18429231.
2002
Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.
The Journal of comparative neurology. 446(3):257-66 [PMID] 11932941.
View on: PubMed
2002
Repeated, intermittent treatment with amphetamine induces neurite outgrowth in rat pheochromocytoma cells (PC12 cells).
Brain research. 951(1):43-52 [PMID] 12231455.
View on: PubMed
2002
Selective release of calpain produced alphalI-spectrin (alpha-fodrin) breakdown products by acute neuronal cell death.
Biological chemistry. 383(5):785-91 [PMID] 12108543.
View on: PubMed
2002
Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 22(8):951-8 [PMID] 12172380.
View on: PubMed
2002
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Journal of neurochemistry. 80(4):579-88 [PMID] 11841565.
View on: PubMed
2001
Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats.
Journal of Neurochemistry. 78(6):1297-306 [DOI] 10.1046/j.1471-4159.2001.00510.x. [PMID] 11579138.

Grants

Jul 2021 ACTIVE
FY22 VA IPA – Fan Lin
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2021 ACTIVE
Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging
Role: Other
Funding: NATL INST OF HLTH OD
Sep 2020 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2020 – Aug 2021
IPA for Jiepei Zhu
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Aug 2020 ACTIVE
Analytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2020 ACTIVE
Combinatorial biosignatures of network dysfunction to predict post-traumatic epilepsy: clinical translation from a robust mouse model
Role: Principal Investigator
Funding: MARIO NEGRI INSTITUTE via US ARMY MED RES ACQUISITION
Jun 2020 – May 2021
Transforming Research And Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NINDS
Feb 2020 ACTIVE
Project 1: Tau, Synapsin Biomarker Testing on Gryphon-provided biofluid biosamples, with Additional Testing on four other biomarkers
Role: Principal Investigator
Funding: GRYPHON BIO
Sep 2019 – Sep 2021
PROOF-OF-PRINCIPLE TESTING OF TAU-SPECIFIC APTAMERS IN TBI-LINKED TAUOPATHY MODEL
Role: Principal Investigator
Funding: GRYPHON BIO via US ARMY MED RES ACQUISITION
May 2019 ACTIVE
Biomarker-based Precision Medicine Approach to Traumatic Brain Injury Subphenotypes
Role: Principal Investigator
Funding: SUNY DOWNSTATE MEDICAL CENTER via US ARMY MED RES ACQUISITION
Dec 2018 – May 2019
Evaluating the Use of Biofluid-based Biomarkers in pig samples as part of TBI Drug Development
Role: Principal Investigator
Funding: NEUROVIVE PHARMACEUTICAL AB
Sep 2018 – Sep 2021
TRACK-TBI Precision Medicine – Pathomechanistic Classification of Traumatic Brain Injury: The Bridge to Targeted Therapies
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES ACQUISITION
Sep 2018 ACTIVE
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Network (TRACK-TBI NET)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES AND DEVELOPMENT COMMAND
May 2018 – Apr 2020
Animal TBI and neuroinflammation and autoimmunity responses
Role: Principal Investigator
Funding: MARIO NEGRI INSTITUTE
Apr 2018 – Mar 2021
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2018 ACTIVE
Identifying proteomic, metabolomic and microRNA biomarkers signifying spontaneous post-traumatic epilepsy in a rat model of penetrating ballistic brain injury
Role: Principal Investigator
Funding: CURE-CITIZENS UNITED FOR RES IN EPILEPSY via US ARMY MED RES AND DEVELOPMENT COMMAND
Sep 2017 – Sep 2021
Biomedical Research: Housing of mice to conduct brain research
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2017 – Sep 2018
Task Order #1 – Evaluating the use of biofluid-based biomarkers in TBI drug development study
Role: Principal Investigator
Funding: NEUROVIVE PHARMACEUTICAL AB
Apr 2017 – Mar 2020
International Collaboration On Neuroinflammation in Traumatic Brain Injury (ICON-TBI)
Role: Principal Investigator
Funding: UNIVERSITY OF CAMBRIDGE via NETWORK OF EUROPEAN FUNDING NEUROSCIENCE
Mar 2017 – Mar 2019
Evaluation of Tau and Phospho-Tau as TBI Biomarkers on the hs-HISCL Platform: Phase I
Role: Principal Investigator
Funding: SYSMEX CORPORATION
Apr 2016 – Mar 2020
TGF-BETA SIGNALING AS A NOVEL THERAPEUTIC TARGET FOR MILDTRAUMATIC BRAIN INJURY
Role: Principal Investigator
Funding: PALO ALTO VETERANS INST FOR RES via NATL INST OF HLTH NINDS
Mar 2016 – Jun 2019
BIOMARKERS OF SUBACUTE AND CHRONIC TBI
Role: Project Manager
Funding: SALEM VA MEDICAL CENTER
Jan 2016 – Jul 2016
Blade in vivo mouse fibrosis model with calpain inhibitors – calpain biomarker study
Role: Principal Investigator
Funding: BLADE THERAPEUTICS INC
Jan 2016 – Jan 2016
Enhancing the "regulatory readiness" of top 5 TBI biomarkers towards FDA drug development "Biomarker Qualification Program"
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US DEPT OF DEFENSE
Sep 2014 – Sep 2021
TBI Endpoints Development (TED)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via US ARMY MED RES AND DEVELOPMENT COMMAND
Sep 2014 – Sep 2017
Biomarker Signatures in Blood for Acute and Chronic mTBI Using the SOFIA Technology
Role: Principal Investigator
Funding: STATE UNIV OF NEW YORK RES FOU via US ARMY MED RES ACQUISITION
Sep 2014 – Sep 2017
Biomarkers for Spinal Cord Injury-Related Medical Complications
Role: Principal Investigator
Funding: UNIV OF MIAMI via US ARMY MED RES ACQUISITION
Jul 2014 – Dec 2018
The Role of the Intestinal Microbiota in the Development of Anxiety and Depression in Breast Cancer Patients Receiving Chemotherapy.
Role: Project Manager
Funding: FL BREAST CANCER FOU
May 2014 – Apr 2017
Elucidate Consequences of Autoimmune Response to Protease-modified GFAP in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
May 2014 – Apr 2016
OBTT Extended Studies
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via US ARMY MED RES ACQUISITION
Oct 2013 – Mar 2021
COLLABORATIVE EUROPEAN NEUROTRAUMA EFFECTIVENESS RESEARCH(CENTER) TBICENTER-TBI
Role: Principal Investigator
Funding: UNIVERSITAIR ZIEKENHUIS ANTWERPEN via EUROPEAN UNION
Sep 2013 – Aug 2020
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NINDS
Jul 2013 – Jun 2018
Dr. Wang's Multtiple Sponsors
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Sep 2012 – Sep 2016
Biomarkers for Spinal Cord Injury-Related Medical Complications Award Mechanism: Translational Research Partnership
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2011 – Sep 2016
Operation Brain Trauma Therapy (OBTT)
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via US ARMY MED RES ACQUISITION
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Patents

Issued November 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 13629]
#9,810,695
Published November 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 14378]
#US-2018-0059123-A1
Issued May 2017
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders [CON of 11330]
#9,664,694
Published November 2016
Protein Biomarkers for Acute, Subacute and Chronic Traumatic Injuries of the Central Nervous System
#2017-0146555 A1
Published September 2014
Endothelial-Monocyte Activating Polypeptide II (EMAP-II) As Brain Injury or Organ Injury Biomarker
#2015-0057193 A1
Issued October 2013
Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury (CIP of PCT)
#8,557,526
Issued July 2013
Neural Proteins as BioMarkers for Nervous System Injury and Other Neural Disorders (CIP)
#8,492,107
Issued October 2012
Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining
#8,298,835
Published May 2012
In Vitro Diagnostic Devices for Nervous System Injury and Other Neural Disorders (CIP of 13629)
#US-2014-0303041-A1
Published December 2011
Biomarkers of Traumatic Brain Injury
#US-2012-0196307-A1
Issued November 2011
Biomarkers of Liver Ischemic Injury (CIP)
#8,048,638
Issued September 2010
Endothelial-Monocyte Activating Polypeptide II (EMAP-II) As Brain Injury or Organ Injury Biomarker
#7799536
Issued January 2010
Biomarkers of Liver Ischemic Injury
#7,645,584
Issued November 2009
Detection of Cannabinoid Receptor Biomarkers and Uses Thereof (CIP of 11619)
#7,611,858
Issued November 2008
Proteolytic Biomarkers for Traumatic Injury to the Nervous System
#7,456,027
Issued July 2008
Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders
#7,396,654
Published June 2008
Neural Proteins as BioMarkers for Nervous System Injury and Other Neural Disorders (DIV of 11330)
#UF-2009-0087868-A1
Published November 2007
Imaging of Neural and Organ Injury or Damage
#US-2008-0311036-A1
Issued November 2007
Detection of Spectrin and Spectrin Proteolytic Cleavage Products in Assessing Nerve Cell Damage
#7,291,710
Published April 2007
Real-Time Assessment of Biomarkers in Biological Fluids for Human Disease and Wellness and for Pathogen Contamination Monitoring in Water/fluid Supplies
#US-2008-0204043 A1
Issued May 2006
Novel Application of Nanotechnology and Sensor Technologies for In Vitro Diagnostics
#7,052,854

Teaching Profile

Courses Taught
2018-2019,2021
IDH3931 Interdisciplinary Junior Honors
2018
MDT7090 Elective Topics
2018
CHM7980 Research for Doctoral Dissertation
2014
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 294-4933
Emails:
Business:
kwang@ufl.edu