Firas H Kobaissy

Firas H Kobaissy, Ph.D.

Research Assistant Professor & Associate Director NNBR

Department: Department of Emergency Medicine
Business Phone: (352) 265-5911

About Firas H Kobaissy

Firas H. Kobaissy received a Ph.D. in molecular Neuroscience from the University of Florida (Gainesville) under the direction of Dr. Kevin K. Wang and Dr. Mark S. Gold. Most of his research focused on brain injury due to mechanical insult or due to drug abuse neurotoxicity using rat model. Dr. Kobaissy utilizes the state of the art proteomics tools to investigate cell death mechanisms involved in different brain insults.

In his Ph.D., Dr. Kobaissy utilized the controlled cortical impact (CCI) rat model to evaluate protein dynamics after acute brain injury. In his Post doctoral training, he translated his work to study the proteomics changes involved in drug abuse particularly in methamphetamine and MDMA. Dr. Kobeissy is the author of several articles, reviews, and book chapters along with three international patents. He is the Associate Scientific Director for the Psychoproteomics and Nanotechnology Research Center. In 2008, Dr. Kobaissy joined the Department of Psychiatry and the Division on Addiction Medicine as Research Assistant Professor.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5008-6944

Publications

2021
Characterization of Traumatic Brain Injury Research in the Middle East and North Africa Region: A Systematic Review
Neuroepidemiology. 1-12 [DOI] 10.1159/000511554.
2021
Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap
Nature Reviews Neurology. [DOI] 10.1038/s41582-021-00461-4.
2021
Neurological and Neuropsychological Changes Associated with SARS-CoV-2 Infection: New Observations, New Mechanisms
The Neuroscientist. [DOI] 10.1177/1073858420984106.
2021
Sweat metabolome and proteome: Recent trends in analytical advances and potential biological functions.
Journal of proteomics. 246 [DOI] 10.1016/j.jprot.2021.104310. [PMID] 34198014.
2021
Therapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I:C)-stimulated macrophages
Cancer Gene Therapy. [DOI] 10.1038/s41417-020-00286-1.
2021
Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury
Acute Medicine & Surgery. 8(1) [DOI] 10.1002/ams2.622. [PMID] 33510896.
2021
Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
Journal of Cellular Physiology. [DOI] 10.1002/jcp.30345.
2020

Prevalence of Eating Disorders Among Medical Students in a Lebanese Medical School: A Cross-Sectional Study

Neuropsychiatric Disease and Treatment. Volume 16:1879-1887 [DOI] 10.2147/ndt.s266241.
2020

Telepsychiatry in the Arab World: A Viewpoint Before and During COVID-19

Neuropsychiatric Disease and Treatment. Volume 16:2805-2815 [DOI] 10.2147/ndt.s277224.
2020
Advances in Cardiovascular Biomarker Discovery
Biomedicines. 8(12) [DOI] 10.3390/biomedicines8120552. [PMID] 33265898.
2020
Circulating Brain Injury Exosomal Proteins following Moderate-to-Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications
Cells. 9(4) [DOI] 10.3390/cells9040977. [PMID] 32326450.
2020
Drug Repurposing in Neurological Disorders: Implications for Neurotherapy in Traumatic Brain Injury
The Neuroscientist. [DOI] 10.1177/1073858420961078.
2020
Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury
Current Medicinal Chemistry. 27 [DOI] 10.2174/0929867327666200812221022.
2020
EPAC in Vascular Smooth Muscle Cells
International Journal of Molecular Sciences. 21(14) [DOI] 10.3390/ijms21145160. [PMID] 32708284.
2020
Epigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages under Antitumoral Resistance Induced by IL-10
ACS Omega. 5(43):27774-27782 [DOI] 10.1021/acsomega.0c02530. [PMID] 33163760.
2020
Location of neonatal microglia drives small extracellular vesicles content and biological functions in vitro
Journal of Extracellular Vesicles. 9(1) [DOI] 10.1080/20013078.2020.1727637. [PMID] 32158520.
2020
Modulation of proteomic and inflammatory signals by Bradykinin in podocytes
Journal of Advanced Research. 24:409-422 [DOI] 10.1016/j.jare.2020.05.021. [PMID] 32518694.
2020
Protein Expression Analysis of an In Vitro Murine Model of Prostate Cancer Progression: Towards Identification of High-Potential Therapeutic Targets
Journal of Personalized Medicine. 10(3) [DOI] 10.3390/jpm10030083. [PMID] 32784957.
2020
Repurposing of Acriflavine to target Chronic Myeloid Leukemia treatment
Current Medicinal Chemistry. 27 [DOI] 10.2174/0929867327666200908114411.
2020
Secretome Analysis of Inductive Signals for BM-MSC Transdifferentiation into Salivary Gland Progenitors
International Journal of Molecular Sciences. 21(23) [DOI] 10.3390/ijms21239055. [PMID] 33260559.
2020
Serum Glycomics Profiling of Patients with Primary Restless Legs Syndrome Using LC–MS/MS
Journal of Proteome Research. 19(8):2933-2941 [DOI] 10.1021/acs.jproteome.9b00549.
2020
The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
International Journal of Molecular Sciences. 21(14) [DOI] 10.3390/ijms21144962. [PMID] 32674299.
2020
The Role of Epac in Cancer Progression
International Journal of Molecular Sciences. 21(18) [DOI] 10.3390/ijms21186489. [PMID] 32899451.
2020
Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone
Antioxidants. 9(10) [DOI] 10.3390/antiox9100943. [PMID] 33019512.
2020
Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals
Antioxidants. 9(12) [DOI] 10.3390/antiox9121251. [PMID] 33316969.
2019
A shared comparison of diabetes mellitus and neurodegenerative disorders
Journal of Cellular Biochemistry. 120(9):14318-14325 [DOI] 10.1002/jcb.28094.
2019
Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury
Neuropharmacology. 145:177-198 [DOI] 10.1016/j.neuropharm.2018.09.032.
2019
Hydrogels for Advanced Stem Cell Therapies: A Biomimetic Materials Approach for Enhancing Natural Tissue Function
IEEE Reviews in Biomedical Engineering. 12:333-351 [DOI] 10.1109/rbme.2018.2824335.
2019
Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats
Epilepsy & Behavior. 92:332-340 [DOI] 10.1016/j.yebeh.2019.01.023.
2019
Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers
Analytical Chemistry. 91(18):11879-11887 [DOI] 10.1021/acs.analchem.9b02633.
2019
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges
International Journal of Molecular Sciences. 20(20) [DOI] 10.3390/ijms20205213. [PMID] 31640160.
2019
PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype
Cells. 8(12) [DOI] 10.3390/cells8121490. [PMID] 31766635.
2019
Tackling neuroinflammation and cholinergic deficit in Alzheimer’s disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
European Journal of Medicinal Chemistry. 167:161-186 [DOI] 10.1016/j.ejmech.2019.02.012.
2019
Transcriptomic profiling of trophoblast fusion using BeWo and JEG-3 cell lines
Molecular Human Reproduction. 25(12):811-824 [DOI] 10.1093/molehr/gaz061.
2018
Glycosylation Changes in Brain Cancer
ACS Chemical Neuroscience. 9(1):51-72 [DOI] 10.1021/acschemneuro.7b00271. [PMID] 28982002.
2018
Insomnia in hospitalized psychiatric patients: prevalence and associated factors
Neuropsychiatric Disease and Treatment. Volume 14:969-975 [DOI] 10.2147/ndt.s160742.
2018
LC–MS/MS glycomics of idiopathic rapid eye movement sleep behavior disorder
ELECTROPHORESIS. 39(24):3096-3103 [DOI] 10.1002/elps.201800316. [PMID] 30168606.
2018
Lipid Changes Associated with Traumatic Brain Injury Revealed by 3D MALDI-MSI
Analytical Chemistry. 90(17):10568-10576 [DOI] 10.1021/acs.analchem.8b02682.
2017
Acute Exposure to Cigarette Smoking Followed by Myocardial Infarction Aggravates Renal Damage in an In Vivo Mouse Model
Oxidative Medicine and Cellular Longevity. 2017:1-13 [DOI] 10.1155/2017/5135241. [PMID] 29177025.
2017
Functional, Cellular, and Molecular Remodeling of the Heart under Influence of Oxidative Cigarette Tobacco Smoke
Oxidative Medicine and Cellular Longevity. 2017:1-16 [DOI] 10.1155/2017/3759186. [PMID] 28808498.
2017
Traumatic brain injury, diabetic neuropathy and altered-psychiatric health: The fateful triangle
Medical Hypotheses. 108:69-80 [DOI] 10.1016/j.mehy.2017.08.008.
2013
An updated overview of animal models in neuropsychiatry.
Neuroscience. 240:204-18 [DOI] 10.1016/j.neuroscience.2013.02.045. [PMID] 23473749.
2013
Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury.
Journal of neurotrauma. 30(13):1161-9 [DOI] 10.1089/neu.2012.2762. [PMID] 23409698.
2013
Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.
Neuroscience letters. 544:62-7 [DOI] 10.1016/j.neulet.2013.03.042. [PMID] 23570732.
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Nucleus Tractus Solitaries and Oxidative Stress in the Hypothalamus in Rats
Journal of Neurotrauma. 29
2012
Blast Brain Injury Elevates Catecholamine Biosynthesis in the Rat Adrenal Medulla
The FASEB's Journal. 26
2012
Characterization of Beta Ii-Spectrin Degradation Under Both Excitotoxic Challenge and After Traumatic Brain Injury
Journal of Neurotrauma. 29
2012
Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines.
PloS one. 7(11) [DOI] 10.1371/journal.pone.0049021. [PMID] 23145051.
2012
In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system.
Electrophoresis. 33(24):3786-97 [DOI] 10.1002/elps.201200326. [PMID] 23161537.
2012
Mass Spectrometry-Based Identification and Quantitation of Proteins Released in Traumatic Brain Injury Cell Culture Model
Journal of Neurotrauma. 29:A98-A99
2012
Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells.
Cytokine. 60(3):806-11 [DOI] 10.1016/j.cyto.2012.08.003. [PMID] 22944462.
2012
Neuroproteomics Approach and Neurosystems Biology Analysis: Rock Inhibitors as Promising Therapeutic Targets in Neurodegeneration and Neurotrauma
Electrophoresis. 33(24):3659-3668 [DOI] 10.1002/elps.201200470. [PMID] 23161464.
2012
Proteomic Analysis and Brain-Specific Systems Biology in a Rodent Model of Penetrating Ballistic-Like Brain Injury
Electrophoresis. 33(24):3693-3704 [DOI] 10.1002/elps.201200196. [PMID] 23161467.
2012
Systems Biology Approach in Pathway Analysis of Low Dose Flagellin Induced Tolerance To Flagellin-Stimulated Inflammation in Caco-2 Cells
The FASEB's Journal. 26
2011
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.
ASN neuro. 3(1) [DOI] 10.1042/AN20100012. [PMID] 21359008.
2011
Effects of Oxyten in An Invertebrate Model of Amphetamine Neurotoxicity
Biological Psychiatry. 69
2011
Identification of tyrosine nitration in UCH-L1 and GAPDH.
Electrophoresis. 32(13):1692-705 [DOI] 10.1002/elps.201100133. [PMID] 21706495.
2010
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
BMC neuroscience. 11 [DOI] 10.1186/1471-2202-11-21. [PMID] 20167092.
2010
Food addiction and obesity: evidence from bench to bedside.
Journal of psychoactive drugs. 42(2):133-45 [PMID] 20648909.
View on: PubMed
2010
Food addiction and obesity: evidence from bench to bedside.
Journal of Psychoactive Drugs. 42(2) [DOI] 10.1080/02791072.2010.10400686. [PMID] 20648909.
2010
Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats.
Pharmacology, biochemistry, and behavior. 95(4):401-9 [DOI] 10.1016/j.pbb.2010.02.018. [PMID] 20211642.
2010
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
The European journal of neuroscience. 31(4):722-32 [DOI] 10.1111/j.1460-9568.2010.07097.x. [PMID] 20384815.
2009
Characteristics of Drinkers, Binge Drinkers, and Abstainers At College Football Tailgating Festivities
Alcoholism-Clinical and Experimental Research. 33
2009
Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation.
Stem cells (Dayton, Ohio). 27(2):280-9 [DOI] 10.1634/stemcells.2008-0842. [PMID] 18988710.
2009
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates.
Biological psychiatry. 66(2):118-27 [DOI] 10.1016/j.biopsych.2009.02.021. [PMID] 19345341.
2009
Methods in drug abuse neuroproteomics: methamphetamine psychoproteome.
Methods in molecular biology (Clifton, N.J.). 566:217-28 [DOI] 10.1007/978-1-59745-562-6_15. [PMID] 20058175.
2008
Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats.
Addiction biology. 13(1):15-25 [PMID] 17910739.
View on: PubMed
2008
Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation.
Proteomics. Clinical applications. 2(10-11):1467-83 [DOI] 10.1002/prca.200800011. [PMID] 21136795.
2008
Psychiatric research: psychoproteomics, degradomics and systems biology.
Expert review of proteomics. 5(2):293-314 [DOI] 10.1586/14789450.5.2.293. [PMID] 18466058.
2008
Psychoproteomic analysis of rat cortex following acute methamphetamine exposure.
Journal of proteome research. 7(5):1971-83 [DOI] 10.1021/pr800029h. [PMID] 18452277.
2008
Traumatic Brain Injury Biomarkers: a Neuroproteomic-Based Discovery, Systems Biology-Based Selection and Validation in Animal Studies
Journal of Neurotrauma. 25
2008
Using Psychoproteomics To Identify Protein Pathways Relevant To Methamphetamine Neurotoxicity
Biological Psychiatry. 63
2007
Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.
Acta neuropathologica. 114(3):277-86 [PMID] 17647000.
View on: PubMed
2007
Novel neuroproteomic approaches to studying traumatic brain injury.
Progress in brain research. 161:401-18 [PMID] 17618994.
View on: PubMed
2006
Novel differential neuroproteomics analysis of traumatic brain injury in rats
Molecular & Cellular Proteomics. (5):1887-1898
2005
A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry.
Analytical chemistry. 77(15):4836-45 [PMID] 16053296.
View on: PubMed
2005
Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury.
Life sciences. 78(3):301-9 [PMID] 16125733.
View on: PubMed
On-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
. [DOI] 10.1101/2020.10.02.324434.
Preneoplastic lesions fimbria pan-proteomic studies establish the fimbriectomy benefit for BRCA1/2 patients and identify early diagnosis markers of HGSC
. [DOI] 10.1101/2020.10.04.325100.

Grants

Sep 2020 ACTIVE
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2020 ACTIVE
Analytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2020 – Aug 2020
Firas Kobaissy FY21 VA IPA – updated
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jul 2019 – Jul 2021
FY20 VA IPA for Kobaissy
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Apr 2018 – Mar 2021
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2018 ACTIVE
Identifying proteomic, metabolomic and microRNA biomarkers signifying spontaneous post-traumatic epilepsy in a rat model of penetrating ballistic brain injury
Role: Co-Investigator
Funding: CURE-CITIZENS UNITED FOR RES IN EPILEPSY via US ARMY MED RES AND DEVELOPMENT COMMAND

Patents

Issued October 2013
Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury (CIP of PCT)
#8,557,526
Published December 2011
Biomarkers of Traumatic Brain Injury
#US-2012-0196307-A1

Contact Details

Phones:
Business:
(352) 265-5911