Faheem W Guirgis, MD, FACEP
Vice Chair Of Research; Professor; Co-Director, CTSI KL2 Program
Department:
Department of Emergency Medicine
Business Phone:
(352) 265-5911
Business Email:
fguirgis@ufl.edu
About Faheem W Guirgis
Faheem W. Guirgis, M.D., is an endowed professor of emergency medicine at the University of Florida. His research program’s goal is to define the pathophysiologic role of lipids and lipoproteins in mediating organ failure, inflammation, and recovery from sepsis and to discover precision medicine treatments. He designed a Phase I and Phase II clinical trial testing the safety and efficacy of a lipid emulsion for stabilizing cholesterol levels in septic shock. He has been the recipient of multiple NIH awards to fund his research. Dr. Guirgis has also been a proponent and leader of research education and is MPI and Co-director of the UF-FSU NCATS KL2 Program.
Additional Positions:
Director, Center for Research Training
2019 – Current
·
Associate Professor of Emergency Medicine
2018 – Current
·
University of Florida College of Medicine – Jacksonville
Program Director, Emergency Medicine and Acute Care Research Fellowship
2018 – Current
·
Teaching Profile
Courses Taught
2018
MDC7710 Sr Emerg Med Clerkshp
Board Certifications
-
Emergency MedicineAmerican Board of Emergency Medicine
Clinical Profile
Specialties
- Emergency Medicine
Research Profile
Dr. Guirgis’ clinical and research work focuses on sepsis, and more specifically on mechanisms of lipid dysregulation, clinical implications, and novel therapies. Dr. Guirgis has been the PI of numerous clinical trials and translational research projects in sepsis and critical care, including the LIPid Intensive Drug therapy for Sepsis-Pilot (LIPIDS-P) of his own design. He has a diverse portfolio of active research funding from NIH and other sources. Dr. Guirgis has been recognized for his role in the design of a novel Sepsis Alert Program implemented at UF Health Jacksonville which has led to improved outcomes in patients admitted with sepsis.
Open Researcher and Contributor ID (ORCID)
0000-0002-4445-3939
Publications
2024
Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery.
Annals of surgery open : perspectives of surgical history, education, and clinical approaches.
5(2)
[DOI] 10.1097/AS9.0000000000000429.
[PMID] 38911666.
2024
Lipidomic changes in a novel sepsis outcome‐based analysis reveals potent pro‐inflammatory and pro‐resolving signaling lipids
Clinical and Translational Science.
17(3)
[DOI] 10.1111/cts.13745.
[PMID] 38488489.
2024
Racial disparities in septic shock mortality: a retrospective cohort study.
Lancet regional health. Americas.
29
[DOI] 10.1016/j.lana.2023.100646.
[PMID] 38162256.
2024
The Lipid Intensive Drug Therapy for Sepsis Phase II Pilot Clinical Trial.
Critical care medicine.
52(8):1183-1193
[DOI] 10.1097/CCM.0000000000006268.
[PMID] 38488429.
2024
TRENDS IN CHOLESTEROL AND LIPOPROTEINS ARE ASSOCIATED WITH ACUTE RESPIRATORY DISTRESS SYNDROME INCIDENCE AND DEATH AMONG SEPSIS PATIENTS.
Shock (Augusta, Ga.).
61(2):260-265
[DOI] 10.1097/SHK.0000000000002295.
[PMID] 38407817.
2023
Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis.
Critical care explorations.
5(2)
[DOI] 10.1097/CCE.0000000000000860.
[PMID] 36751516.
2023
Association of Early Serum Phosphate Levels and Mortality in Patients with Sepsis.
The western journal of emergency medicine.
24(3):416-423
[DOI] 10.5811/westjem.58959.
[PMID] 37278802.
2023
Clinical predictors of endotracheal intubation in patients presenting to the emergency department with angioedema.
The American journal of emergency medicine.
63:44-49
[DOI] 10.1016/j.ajem.2022.10.017.
[PMID] 36327748.
2023
DHCR7 Expression Predicts Poor Outcomes and Mortality from Sepsis.
Research square.
[DOI] 10.21203/rs.3.rs-2500497/v1.
[PMID] 36778468.
2023
DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis.
Critical care explorations.
5(6)
[DOI] 10.1097/CCE.0000000000000929.
[PMID] 37332366.
2023
Overtriage, Undertriage, and Value of Care after Major Surgery: An Automated, Explainable Deep Learning-Enabled Classification System.
Journal of the American College of Surgeons.
236(2):279-291
[DOI] 10.1097/XCS.0000000000000471.
[PMID] 36648256.
2023
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
The journal of trauma and acute care surgery.
95(5):790-799
[DOI] 10.1097/TA.0000000000004087.
[PMID] 37561664.
2022
Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19
Viruses.
14(3)
[DOI] 10.3390/v14030553.
[PMID] 35336960.
2022
Efficacy of Losartan in Hospitalized Patients With COVID-19-Induced Lung Injury: A Randomized Clinical Trial.
JAMA network open.
5(3)
[DOI] 10.1001/jamanetworkopen.2022.2735.
[PMID] 35294537.
2021
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes
Critical Care.
25(1)
[DOI] 10.1186/s13054-021-03757-5.
[PMID] 34535154.
2021
HDL and persistent inflammation immunosuppression and catabolism syndrome.
Current opinion in lipidology.
32(5):315-322
[DOI] 10.1097/MOL.0000000000000782.
[PMID] 34374677.
2021
Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness
Journal of Clinical Medicine.
10(8)
[DOI] 10.3390/jcm10081693.
[PMID] 33920038.
2021
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis
Annals of Intensive Care.
11(1)
[DOI] 10.1186/s13613-021-00865-x.
[PMID] 34018068.
2021
Most emergency department patients meeting sepsis criteria are not diagnosed with sepsis at discharge.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
28(7):745-752
[DOI] 10.1111/acem.14265.
[PMID] 33872430.
2021
Quantitative and Qualitative Assessments of Cholesterol Association With Bacterial Infection Type in Sepsis and Septic Shock
Journal of Intensive Care Medicine.
36(7):808-817
[DOI] 10.1177/0885066620931473.
[PMID] 32578468.
2021
Updates and controversies in the early management of sepsis and septic shock.
Emergency medicine practice.
23(Suppl 4-2):1-24
[PMID] 33852263.
2020
Development of a Simple Sequential Organ Failure Assessment Score for Risk Assessment of Emergency Department Patients With Sepsis.
Journal of intensive care medicine.
35(3):270-278
[DOI] 10.1177/0885066617741284.
[PMID] 29141524.
2020
Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial.
Journal of the American College of Emergency Physicians open.
1(6):1332-1340
[DOI] 10.1002/emp2.12237.
[PMID] 33392541.
2020
Response to Editor letter “Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis”.
Journal of critical care.
56:319-320
[DOI] 10.1016/j.jcrc.2019.04.024.
[PMID] 31056223.
2020
Response to the Letter: “Bias estimation of predictors and internal validity of the study ‘Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis'”.
Journal of critical care.
56
[DOI] 10.1016/j.jcrc.2019.04.023.
[PMID] 31060766.
2020
Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis
Journal of Intensive Care Medicine.
35(8):810-817
[DOI] 10.1177/0885066618795400.
[PMID] 30165769.
2020
Time to vasopressor initiation and organ failure progression in early septic shock.
Journal of the American College of Emergency Physicians open.
1(3):222-230
[DOI] 10.1002/emp2.12060.
[PMID] 33000037.
2019
Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis.
Journal of critical care.
51:145-148
[DOI] 10.1016/j.jcrc.2019.02.023.
[PMID] 30825788.
2019
Barriers to Utilizing Social Media Platforms in Emergency Medicine Residency Programs.
Cureus.
11(10)
[DOI] 10.7759/cureus.5856.
[PMID] 31763079.
2019
LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock
BMJ Open.
9(9)
[DOI] 10.1136/bmjopen-2019-029348.
[PMID] 31537565.
2019
PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.
PloS one.
14(2)
[DOI] 10.1371/journal.pone.0210808.
[PMID] 30726226.
2018
Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial.
JAMA network open.
1(8)
[DOI] 10.1001/jamanetworkopen.2018.6076.
[PMID] 30646314.
2018
HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.
Shock (Augusta, Ga.).
50(1):66-70
[DOI] 10.1097/SHK.0000000000001030.
[PMID] 29049133.
2018
HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock
PLOS ONE.
13(9)
[DOI] 10.1371/journal.pone.0203813.
[PMID] 30216360.
2018
Points & Pearls: Updates and controversies in the early management of sepsis and septic shock.
Emergency medicine practice.
20(Suppl 10):1-2
[PMID] 30280868.
2018
Updates and controversies in the early management of sepsis and septic shock.
Emergency medicine practice.
20(10):1-28
[PMID] 30252228.
2017
Clinical predictors of early death from sepsis.
Journal of critical care.
42:30-34
[DOI] 10.1016/j.jcrc.2017.06.024.
[PMID] 28668774.
2017
Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation.
Shock (Augusta, Ga.).
48(5):539-544
[DOI] 10.1097/SHK.0000000000000887.
[PMID] 28452909.
2017
Managing sepsis: Electronic recognition, rapid response teams, and standardized care save lives.
Journal of critical care.
40:296-302
[DOI] 10.1016/j.jcrc.2017.04.005.
[PMID] 28412015.
2017
Naloxone Triggering the RRT: A Human Antidote?
Journal of patient safety.
13(1):20-24
[DOI] 10.1097/PTS.0000000000000099.
[PMID] 24618648.
2017
The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
Critical care medicine.
45(9):1436-1442
[DOI] 10.1097/CCM.0000000000002512.
[PMID] 28542029.
2016
Cholesterol levels and long-term rates of community-acquired sepsis.
Critical care (London, England).
20(1)
[DOI] 10.1186/s13054-016-1579-8.
[PMID] 28010729.
2016
End-tidal carbon dioxide and occult injury in trauma patients: ETCO2 does not rule out severe injury.
The American journal of emergency medicine.
34(11):2146-2149
[DOI] 10.1016/j.ajem.2016.08.007.
[PMID] 27567419.
2016
The long-term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction.
The journal of trauma and acute care surgery.
81(3):525-32
[DOI] 10.1097/TA.0000000000001135.
[PMID] 27398984.
2016
Ultrasound-Guided Peripheral Intravenous Catheter Training Results in Physician-Level Success for Emergency Department Technicians.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
35(11):2343-2352
[PMID] 27629755.
2015
The bubble study: ultrasound confirmation of central venous catheter placement.
The American journal of emergency medicine.
33(3):315-9
[DOI] 10.1016/j.ajem.2014.10.010.
[PMID] 25550065.
2015
The relationship of intravenous fluid chloride content to kidney function in patients with severe sepsis or septic shock.
The American journal of emergency medicine.
33(3):439-43
[DOI] 10.1016/j.ajem.2014.12.013.
[PMID] 25650359.
2014
Carotid intima media thickness and low high-density lipoprotein (HDL) in South Asian immigrants: could dysfunctional HDL be the missing link?
Archives of medical science : AMS.
10(5):870-9
[DOI] 10.5114/aoms.2014.46208.
[PMID] 25395937.
2014
End-tidal carbon dioxide as a goal of early sepsis therapy.
The American journal of emergency medicine.
32(11):1351-6
[DOI] 10.1016/j.ajem.2014.08.036.
[PMID] 25205615.
2014
Impact of an abbreviated cardiac enzyme protocol to aid rapid discharge of patients with cocaine-associated chest pain in the clinical decision unit.
The western journal of emergency medicine.
15(2):180-3
[DOI] 10.5811/westjem.2013.11.19232.
[PMID] 24672608.
2014
Long-Term Organ Dysfunction After Severe Sepsis
Critical Care Medicine.
42(12, S)
2014
Persistent organ dysfunction after severe sepsis: a systematic review.
Journal of critical care.
29(3):320-6
[DOI] 10.1016/j.jcrc.2013.10.020.
[PMID] 24360598.
2013
Proactive rounding by the rapid response team reduces inpatient cardiac arrests.
Resuscitation.
84(12):1668-73
[DOI] 10.1016/j.resuscitation.2013.08.013.
[PMID] 23994805.
2013
Rapid Discharge of Patients Presenting To the Emergency Department With Cocaine Chest Pain: Application of An Abbreviated Cardiac Enzyme Protocol in the Clinical Decision Unit
Annals of Emergency Medicine.
62
2013
Successful Implementation of Proactive Rounding By a Rapid Response Team in a Tertiary, Academic, Level 1 Trauma Center Reduces Inpatient Cardiac Arrests and Facilitates Preemptive Transfer To a Higher Level of Care
Annals of Emergency Medicine.
62
Grants
Mar 2024
ACTIVE
Understanding pathology of sepsis-induced physical disability for future precision medicine
Role: Principal Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM
via NATL INST OF HLTH NIGMS
Sep 2023
ACTIVE
Assessing performance of a Hepatitis C Emergency Department (HepC-END) Screening Tool
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Aug 2023
– Mar 2024
Understanding pathology of sepsis-induced physical disability for future precision medicine
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2023
ACTIVE
Institutional Career Development Core
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Jul 2023
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Jun 2023
ACTIVE
UFR CTSI Instituitonal Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2022
– Jun 2024
Together: Transforming and Translating Discovery to Improve Health
Role: Co-Project Director/Principal Investigator
Funding: NATL INST OF HLTH NCATS
Jul 2022
– Aug 2023
Institutional Career Development Core
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Mar 2022
ACTIVE
Home-based digital exercise training program to improve physical function of older sepsis survivorsHEAL Sepsis Trial
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2021
– Nov 2023
Informing the Emergency Care of Septic Shock Patients: A Novel Application of Data-Driven Analytics
Role: Other
Funding: NATL INST OF HLTH NIGMS
Sep 2021
– Sep 2024
Enhancing U.S. Surveillance of Laboratory Confirmed SARS-CoV-2, Influenza, and other Respiratory Viruses through a Network of Emergency Departments
Role: Principal Investigator
Funding: WAYNE STATE UNIV
via CTRS FOR DISEASE CONTROL AND PREVENTION
Jul 2021
– May 2024
Together: Transforming and Translating Discovery to Improve Health
Role: Other
Funding: NATL INST OF HLTH NCATS
Jul 2021
– Jun 2022
Institutional Career Development Core
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Mar 2021
– Oct 2022
ACTIV 4d RAAS
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via NATL INST OF HLTH NHLBI
Aug 2020
– Apr 2022
Randomized Master Protocol for Immune Modulators for Treating COVID-19
Role: Co-Investigator
Funding: DUKE UNIVERSITY CLINICAL RES INST
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Jun 2020
– Aug 2021
COVID:A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Role: Principal Investigator
Funding: LEIDOS
via NATL INST OF HLTH NCI
Jun 2020
– Nov 2020
COVID-19: Multi-center registry of potential COVID-19 patients presenting to US Emergency Departments
Role: Principal Investigator
Funding: INDIANA UNIV
Apr 2020
– Apr 2021
COVID-19: Angiotensin Receptor blockers for novel SAR-CoV-2
Role: Co-Investigator
Funding: UNIV OF MINNESOTA
via BILL & MELINDA GATES FOUNDATION
Apr 2020
ACTIVE
The Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Sep 2018
– Jun 2023
A 3D Tissue Map of the Human Lymphatic System
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jun 2018
– Jun 2022
OR-DRPD-ROF2018: The LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P) Trial
Role: Principal Investigator
Funding: UF RESEARCH
Jan 2018
– Jun 2020
Vitamin C, Thiamine and Steroids in Sepsis- multi-center, randomized, placebo-controlled, double-blind, adaptive clinical trial of vitamin C, thiamine and steroids as combination therapy in patients with sepsis.
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
via MARCUS FOU
Apr 2017
– Jun 2024
HSC COM Matching Commitment
Role: Project Manager
Funding: UNIV OF FLORIDA
Sep 2016
– Aug 2020
The Role of Dysfunctional HDL in Sepsis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2016
– Mar 2017
TOGETHER: TRANSFORMING AND TRANSLATING DISCOVERY TO IMPROVE ,HEALTH ,
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jan 2015
– Jan 2018
The Role of Dysfunctional HDL in Sepsis
Role: Principal Investigator
Funding: SOCIETY OF CRITICAL CARE MEDICINE
Mar 2014
– May 2018
Rapid Administration of Carnitine in Sepsis (RACE)
Role: Principal Investigator
Funding: UNIVERSITY OF MISSISSIPPI
via NATL INST OF HLTH NIGMS
Education
Emergency Medicine Residency
2010
·
Albert Einstein College of Medicine
Doctor of Medicine
2006
·
Rosalind Franklin University
Contact Details
Phones:
- Business:
- (352) 265-5911
Emails:
- Business:
- fguirgis@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100186
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100186
GAINESVILLE FL 32610